TB-500
Thymosin Beta-4 Fragment - Thymosin β-4 fragment studied for actin regulation and tissue repair.
TB-500 is a synthetic version of the naturally occurring peptide Thymosin β-4. Research interest centers on its regulation of actin, cell migration and its reported role in tissue-repair and flexibility models.
As a synthetic form of the naturally occurring Thymosin β-4, TB-500 is studied less for a single receptor and more for its upstream effect on the actin cytoskeleton, which touches migration, angiogenesis and flexibility endpoints. It is a common comparator and combination partner in tissue-repair protocols alongside BPC-157.
TB-500 specifications
- CAS number
- 77591-33-4
- Molecular formula
- C212H350N56O78S
- Molecular weight
- 4963.44 g/mol
- Sequence
- Synthetic fragment of Thymosin β-4
- Residues
- 43 residues
- Presentation
- Lyophilized powder
- Documented purity
- 99.62% by HPLC
- Available sizes
- 10mg ($80)
- Archived COA lots
- 6
- Intended use
- Laboratory research use only. Not for human or veterinary use.
Studied pathways
- Actin regulation - Binds and sequesters G-actin, a mechanism linked to cell migration and repair in study models.
- Cell migration - Studied for its role in directing reparative cells toward sites of tissue stress.
Reported mechanisms in the literature
- Actin regulation - As a synthetic form of Thymosin β-4, it is studied for binding and sequestering G-actin - a mechanism linked to cell migration and tissue remodeling in repair research. (Goldstein et al.)
- Reparative cell recruitment - Investigated for directing reparative and endothelial cells toward sites of tissue stress, and for its reported role in flexibility and recovery models. (Sosne et al.)
What TB-500 is researched for
- Muscle & tendon recovery - Investigated for flexibility and recovery endpoints tied to actin regulation in injury models. (Goldstein et al.)
- Tissue repair - Studied for reparative cell migration and angiogenesis in cardiac and dermal wound models. (Sosne et al.)
- Corneal healing - Thymosin β-4 has been studied for corneal wound repair and epithelial migration. (Sosne et al.)
TB-500 certificates of analysis on file
Every lot below was tested by an independent laboratory and the full report is published as a PDF. Purity is shown exactly as the report states it. The same records are searchable in the COA library and can be checked on the lot verification page.
| Lot | Tested | Size | Laboratory | HPLC purity | Identity | Certificate |
|---|---|---|---|---|---|---|
| TB-101926-10 | 22 Oct 2026 | 10mg | ILS Laboratories | 99.36% | Confirmed (HPLC retention time) | COA PDF |
| 3XWAU3 | 12 Sep 2026 | 10mg | Freedom Diagnostics | 99.46% | Confirmed (LC-MS/MS) | COA PDF |
| C7T15H | 17 Aug 2026 | 10mg | Freedom Diagnostics | 99.17% | Confirmed (LC-MS/MS) | COA PDF |
| FD-2605270305 | 27 May 2026 | 10mg | Freedom Diagnostics | 99.58% | Confirmed (LC-MS/MS) | COA PDF |
| 600001 | 20 Feb 2026 | 10mg | Freedom Diagnostics | 99.86% | Confirmed (LC-MS/MS) | COA PDF |
| TB10-12222025-J | 24 Dec 2025 | 10mg | Freedom Diagnostics | 99.72% | Confirmed (LC-MS/MS) | COA PDF |
Published literature on TB-500
The mechanisms above trace to peer-reviewed studies indexed on PubMed. These are independent third-party publications, not Aspect Peptides claims. Browse indexed research on PubMed.
TB-500 frequently asked questions
Is TB-500 the same as Thymosin β-4?
TB-500 is a synthetic version of the naturally occurring peptide Thymosin β-4. Some suppliers instead sell a shorter active fragment; ours is documented on the lot COA. It is a research material only.
Is TB-500 approved for human use?
No. It has no regulatory approval for human use and is not a medicine or supplement. All available data is preclinical. It is supplied for in-vitro laboratory research only.
What is TB-500 studied for?
Chiefly actin regulation, cell migration and tissue-repair signaling in animal and cell models. Findings are preclinical and do not describe effects in humans.
Documented to 99.62% purity by HPLC · third-party COA every lot · from $80 · For laboratory research use only.
Related Regenerative & Repair compounds
- BPC-157 - Synthetic pentadecapeptide studied for VEGF and growth-factor receptor signaling.
- BPC-157 / TB-500 - Co-formulated repair-research blend in a single vial.
- BPC-157 / TB-500 / KPV - BPC-157, TB-500 and KPV co-formulated in a single vial.
- GHK-Cu - Copper tripeptide studied in skin-remodeling research.
- KPV - α-MSH C-terminal fragment studied for inflammatory signaling.
- ARA-290 - Erythropoietin-derived peptide studied for neural repair.