GHK-Cu
Copper-Peptide Complex - Copper tripeptide studied in skin-remodeling research.
GHK-Cu is a naturally occurring copper tripeptide complex studied extensively for its role in extracellular-matrix remodeling, collagen synthesis and antioxidant signaling in dermatological research.
GHK-Cu sits at the intersection of peptide and trace-metal biology, and much of its research interest follows from the copper it carries into the cell as much as the tripeptide itself. Gene-expression studies have made it one of the more mechanistically characterized compounds in skin and matrix research.
GHK-Cu specifications
- CAS number
- 49557-75-7
- Molecular formula
- C14H24CuN6O4
- Molecular weight
- 403.9 g/mol
- Sequence
- Glycyl-L-histidyl-L-lysine · Cu²⁺
- Residues
- Tripeptide · Cu²⁺
- Presentation
- Blue lyophilized powder
- Documented purity
- 99.90% by HPLC
- Available sizes
- 50mg ($30), 100mg ($50)
- Archived COA lots
- 17
- Intended use
- Laboratory research use only. Not for human or veterinary use.
Studied pathways
- Matrix remodeling - Studied for modulation of collagen and glycosaminoglycan synthesis in fibroblast models.
- Copper transport - Acts as a copper-delivery complex, a mechanism linked to numerous downstream enzymatic pathways.
Reported mechanisms in the literature
- Collagen & ECM - Studied for modulation of collagen and glycosaminoglycan synthesis and for gene-expression shifts associated with skin remodeling in fibroblast models. (Pickart et al.)
- Cu²⁺ delivery - Acts as a copper-delivery complex - a mechanism linked to numerous downstream antioxidant and enzymatic pathways studied in dermatological research. (Pickart & Margolina)
What GHK-Cu is researched for
- Skin remodeling - Studied for collagen and glycosaminoglycan synthesis and matrix remodeling in fibroblast and skin models. (Pickart et al.)
- Tissue regeneration - Investigated for accelerated wound closure and angiogenic signaling in preclinical models. (Pickart & Margolina)
- Cellular protection - Studied for gene-expression shifts associated with antioxidant and anti-inflammatory responses. (Pickart et al.)
GHK-Cu certificates of analysis on file
Every lot below was tested by an independent laboratory and the full report is published as a PDF. Purity is shown exactly as the report states it. The same records are searchable in the COA library and can be checked on the lot verification page.
| Lot | Tested | Size | Laboratory | HPLC purity | Identity | Certificate |
|---|---|---|---|---|---|---|
| GHKCu-101926-100 | 22 Oct 2026 | 100mg | ILS Laboratories | 99.90% | Confirmed (HPLC retention time) | COA PDF |
| GHKCu-101926-50 | 22 Oct 2026 | 50mg | ILS Laboratories | 99.50% | Confirmed (HPLC retention time) | COA PDF |
| SD6F5T | 3 Oct 2026 | 50mg | Freedom Diagnostics | 99.95% | Confirmed (LC-MS/MS) | COA PDF |
| JBG0GP | 12 Sep 2026 | 100mg | Freedom Diagnostics | 99.80% | Confirmed (LC-MS/MS) | COA PDF |
| DPH5K4 | 12 Sep 2026 | 50mg | Freedom Diagnostics | 99.91% | Confirmed (LC-MS/MS) | COA PDF |
| WTW6WT | 31 Aug 2026 | 50mg | Accurate Test Labs | 99.91% | Confirmed (LC-MS/MS) | COA PDF |
| A6S43W | 19 Aug 2026 | 100mg | Accurate Test Labs | 99.88% | Confirmed (LC-MS/MS) | COA PDF |
| Upti2606220279 | 25 Jun 2026 | 50mg | Freedom Diagnostics | 99.95% | Confirmed (LC-MS/MS) | COA PDF |
| GHK100-032026-4 | 21 May 2026 | 100mg | Freedom Diagnostics | 99.79% | Confirmed (LC-MS/MS) | COA PDF |
| Whol2605120139 | 14 May 2026 | 100mg | Freedom Diagnostics | 99.86% | Confirmed (LC-MS/MS) | COA PDF |
| FD-2605110196 | 11 May 2026 | 50mg | Freedom Diagnostics | 99.75% | Confirmed (LC-MS/MS) | COA PDF |
| GHK100-032026-J | 30 Apr 2026 | 100mg | Freedom Diagnostics | 99.63% | Confirmed (LC-MS/MS) | COA PDF |
| FD-2604200589 | 20 Apr 2026 | 100mg | Freedom Diagnostics | 99.90% | Confirmed (LC-MS/MS) | COA PDF |
| See certificate | 10 Mar 2026 | 100mg | Freedom Diagnostics | 99.78% | Confirmed (LC-MS/MS) | COA PDF |
| FD-2602180088 | 18 Feb 2026 | 50mg | Freedom Diagnostics | 99.79% | Confirmed (LC-MS/MS) | COA PDF |
| FD-2602090002 | 11 Feb 2026 | 50mg | Freedom Diagnostics | 99.54% | Confirmed (LC-MS/MS) | COA PDF |
| GHK50-02062026-J | 11 Feb 2026 | 50mg | Freedom Diagnostics | 99.54% | Confirmed (LC-MS/MS) | COA PDF |
GHK-Cu sizes and pricing
| Size | Price | Per mg |
|---|---|---|
| 50mg | $30 | $0.60 per mg |
| 100mg | $50 | $0.50 per mg |
Published literature on GHK-Cu
The mechanisms above trace to peer-reviewed studies indexed on PubMed. These are independent third-party publications, not Aspect Peptides claims. Browse indexed research on PubMed.
GHK-Cu frequently asked questions
What is GHK-Cu?
GHK-Cu is a naturally occurring copper-tripeptide complex (glycyl-L-histidyl-L-lysine bound to copper). It is one of the most-studied peptides in skin and matrix-remodeling research.
Is GHK-Cu approved as a drug?
No. It appears in cosmetic formulations but is not an approved drug for any human therapeutic use. Here it is supplied strictly for laboratory research.
What is GHK-Cu researched for?
Extracellular-matrix remodeling, collagen synthesis, antioxidant signaling and tissue repair - primarily in cell and animal models.
Documented to 99.90% purity by HPLC · third-party COA every lot · from $30 · For laboratory research use only.
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