MOTS-c
Mitochondrial-Derived Peptide - Mitochondrial-derived peptide studied for metabolic regulation.
MOTS-c is a mitochondrial-derived peptide studied for its role as a regulator of metabolic homeostasis and insulin sensitivity in cellular research.
MOTS-c is one of a small class of mitochondrial-derived peptides - encoded by mitochondrial rather than nuclear DNA - which is itself the reason for much of the research attention it receives. Studies focus on its AMPK-linked role in metabolic stress and exercise physiology.
MOTS-c specifications
- CAS number
- 1627580-64-6
- Molecular formula
- C101H152N28O22S2
- Molecular weight
- 2174.6 g/mol
- Sequence
- 16-amino-acid mitochondrial-derived peptide
- Residues
- 16 residues
- Presentation
- Lyophilized powder
- Documented purity
- 99.66% by HPLC
- Available sizes
- 10mg ($40)
- Archived COA lots
- 5
- Intended use
- Laboratory research use only. Not for human or veterinary use.
Studied pathways
- AMPK activation - Investigated for AMPK-pathway activation linked to cellular energy regulation.
Reported mechanisms in the literature
- Metabolic regulation - A mitochondrial-derived peptide studied for AMPK-pathway activation linked to cellular-energy regulation and insulin sensitivity. (Lee et al.)
What MOTS-c is researched for
- Insulin sensitivity - Studied for AMPK-linked metabolic regulation and glucose handling in cellular models. (Lee et al.)
- Metabolic stress - Investigated as a mitochondrial-derived regulator of the metabolic-stress response. (Lee et al.)
MOTS-c certificates of analysis on file
Every lot below was tested by an independent laboratory and the full report is published as a PDF. Purity is shown exactly as the report states it. The same records are searchable in the COA library and can be checked on the lot verification page.
| Lot | Tested | Size | Laboratory | HPLC purity | Identity | Certificate |
|---|---|---|---|---|---|---|
| MOTSC-101926-10 | 22 Oct 2026 | 10mg | ILS Laboratories | 99.86% | Confirmed (HPLC retention time) | COA PDF |
| MTC10 | 19 Aug 2026 | 10mg | Accurate Test Labs | 99.90% | Confirmed (LC-MS/MS) | COA PDF |
| Whol2605130124 | 14 May 2026 | 10mg | Freedom Diagnostics | 99.76% | Confirmed (LC-MS/MS) | COA PDF |
| FD-2605120007 | 11 May 2026 | 10mg | Freedom Diagnostics | 99.59% | Confirmed (LC-MS/MS) | COA PDF |
| MOT10-032026-H | 8 May 2026 | 10mg | Freedom Diagnostics | 99.76% | Confirmed (LC-MS/MS) | COA PDF |
Published literature on MOTS-c
The mechanisms above trace to peer-reviewed studies indexed on PubMed. These are independent third-party publications, not Aspect Peptides claims. Browse indexed research on PubMed.
MOTS-c frequently asked questions
What is MOTS-c?
A mitochondrial-derived peptide - unusually, encoded by mitochondrial DNA - studied as a regulator of metabolic homeostasis and insulin sensitivity in cellular research.
Is MOTS-c approved for human use?
No. It is a research material only, with preclinical data only. It is not a medicine or supplement.
What is it studied for?
AMPK-pathway activation and its role in cellular energy metabolism, primarily in cell and animal models.
Documented to 99.66% purity by HPLC · third-party COA every lot · from $40 · For laboratory research use only.
Related Metabolic compounds
- GLP-1 S - Single-agonist GLP-1 research compound.
- GLP-3 RT - Triple-receptor GLP research compound (GLP-1/GIP/glucagon class).
- GLP-2 TZ - Dual GIP/GLP-1 receptor co-agonist studied in glucose-handling and energy-balance research.
- Cagrilintide - Acylated amylin analogue studied for amylin and calcitonin receptor signaling.
- GLP-3 RT + Cagri - GLP-3 RT (10mg) co-formulated with Cagrilintide (2mg) in one vial.
- 5-Amino-1MQ - Small-molecule NNMT inhibitor studied in metabolism research.