Epithalon
Synthetic Tetrapeptide - Tetrapeptide studied for telomerase and circadian research.
Epithalon is a synthetic tetrapeptide based on epithalamin, a pineal-gland extract, studied for its reported effects on telomerase activity and circadian regulation in aging research.
Epithalon comes out of the Russian peptide-bioregulator tradition, where short peptides are studied for tissue-specific regulatory effects, and it is most associated with telomerase and pineal/circadian research. Much of its literature is preclinical and its mechanisms remain an active area of study.
Epithalon specifications
- CAS number
- 307297-39-8
- Molecular formula
- C14H22N4O9
- Molecular weight
- 390.35 g/mol
- Sequence
- Ala-Glu-Asp-Gly (tetrapeptide)
- Residues
- 4 residues (Ala-Glu-Asp-Gly)
- Presentation
- Lyophilized powder
- Documented purity
- 99.75% by HPLC
- Available sizes
- 50mg ($80)
- Archived COA lots
- 4
- Intended use
- Laboratory research use only. Not for human or veterinary use.
Studied pathways
- Telomerase study - Investigated for telomerase-activation activity in cellular-aging models.
Reported mechanisms in the literature
- Telomerase study - A synthetic tetrapeptide modelled on pineal epithalamin, investigated for telomerase-activation activity and circadian regulation in cellular-aging models. (Khavinson et al.)
What Epithalon is researched for
- Telomere biology - Studied for telomerase-activation endpoints in cellular-aging models. (Khavinson et al.)
- Pineal regulation - Investigated for pineal and circadian-regulation effects in preclinical research. (Khavinson et al.)
Epithalon certificates of analysis on file
Every lot below was tested by an independent laboratory and the full report is published as a PDF. Purity is shown exactly as the report states it. The same records are searchable in the COA library and can be checked on the lot verification page.
| Lot | Tested | Size | Laboratory | HPLC purity | Identity | Certificate |
|---|---|---|---|---|---|---|
| EPI-101926-50 | 22 Oct 2026 | 50mg | ILS Laboratories | 99.40% | Confirmed (HPLC retention time) | COA PDF |
| Auth2604230272 | 27 Apr 2026 | 50mg | Freedom Diagnostics | 99.42% | Confirmed (LC-MS/MS) | COA PDF |
| EPIT50-02112026-J | 18 Feb 2026 | 50mg | Freedom Diagnostics | 99.75% | Confirmed (LC-MS/MS) | COA PDF |
| FD-2602170215 | 17 Feb 2026 | 50mg | Freedom Diagnostics | 99.75% | Confirmed (LC-MS/MS) | COA PDF |
Published literature on Epithalon
The mechanisms above trace to peer-reviewed studies indexed on PubMed. These are independent third-party publications, not Aspect Peptides claims. Browse indexed research on PubMed.
Epithalon frequently asked questions
What is Epithalon?
A synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the pineal extract epithalamin, studied for reported effects on telomerase activity and circadian regulation.
Is Epithalon approved for human use?
No. It is a research material only, with primarily preclinical data. It is not a medicine or supplement.
What is it studied for?
Telomerase activity and circadian/pineal regulation in aging-research models.
Documented to 99.75% purity by HPLC · third-party COA every lot · from $80 · For laboratory research use only.
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