Melanocortin & Tone

Kisspeptin

Hypothalamic Neuropeptide - Upstream regulator of the reproductive hormone axis.

Kisspeptin is a neuropeptide that acts as a master regulator upstream of the hypothalamic-pituitary-gonadal axis, studied extensively in reproductive-endocrinology research.

Kisspeptin sits at the very top of the reproductive hormone cascade, upstream of GnRH, which has made it a heavily studied target in reproductive endocrinology including human clinical work. The Kisspeptin-10 fragment is the common research form.

Kisspeptin specifications

CAS number

374675-21-5

Molecular formula

C63H83N17O14

Molecular weight

1302.45 g/mol

Sequence

Kisspeptin-10 decapeptide

Residues

10 residues (Kisspeptin-10)

Presentation

Lyophilized powder

Documented purity

99.63% by HPLC

Available sizes

10mg ($45)

Archived COA lots

3

Intended use

Laboratory research use only. Not for human or veterinary use.

Studied pathways

• GnRH regulation - Studied for stimulation of gonadotropin-releasing-hormone neurons.

Reported mechanisms in the literature

• GnRH regulation - A neuropeptide acting upstream of the hypothalamic-pituitary-gonadal axis, studied for stimulating gonadotropin-releasing-hormone neurons. (Seminara & de Roux)

What Kisspeptin is researched for

• HPG axis - Studied for stimulation of GnRH neurons at the top of the reproductive cascade. (Seminara et al.)
• Gonadotropin release - Investigated for LH-response endpoints in reproductive-endocrinology research. (de Roux et al.)

Kisspeptin certificates of analysis on file

Every lot below was tested by an independent laboratory and the full report is published as a PDF. Purity is shown exactly as the report states it. The same records are searchable in the COA library and can be checked on the lot verification page.

Published literature on Kisspeptin

The mechanisms above trace to peer-reviewed studies indexed on PubMed. These are independent third-party publications, not Aspect Peptides claims. Browse indexed research on PubMed.

Research notes

Research notes: Kisspeptin

Background

The research form of kisspeptin is kisspeptin-10, the ten-residue C-terminal fragment of the KISS1 gene product and the shortest fragment that fully activates its receptor, GPR54 (also called KISS1R). Interest in it came from human genetics: inactivating GPR54 mutations cause hypogonadotropic hypogonadism and failure to enter puberty (Seminara et al., 2003; de Roux et al., 2003). Kisspeptin was then shown to stimulate release of gonadotropin-releasing hormone (GnRH) through GPR54 (Messager et al., 2005). It sits at the top of the reproductive hormone cascade, upstream of GnRH, which is why it is a standard probe of the hypothalamic-pituitary-gonadal axis.

What the Aspect certificates show

There are 2 certificate records for the 10mg vial, both from Freedom Diagnostics, dated 9 January 2026 and 6 July 2026. Reported HPLC purity is 99.08% and 99.72%. Identity is confirmed by LC-MS/MS, and the appearance is reported as white lyophilized powder. Each full report is available as a PDF on this page and in the COA library.

How it differs from related compounds

Kisspeptin acts at the top of the cascade (kisspeptin, then GnRH, then LH and FSH, then the gonads), so it is not interchangeable with compounds further down. The melanocortin analogs PT-141 and Melanotan II are studied in related central pathways but through melanocortin, not kisspeptin, receptors.

Citations

Seminara SB et al., N Engl J Med 2003 (PMID 14573733). de Roux N et al., Proc Natl Acad Sci U S A 2003 (PMID 12944565). Messager S et al., Proc Natl Acad Sci U S A 2005 (PMID 15665093).

Third-party publications are cited for context and are not Aspect Peptides claims. For laboratory research use only.

Kisspeptin frequently asked questions

Documented to 99.63% purity by HPLC · third-party COA every lot · from $45 · For laboratory research use only.

Related Melanocortin & Tone compounds

• Melanotan II - Melanocortin agonist studied for pigmentation research.
• PT-141 - Bremelanotide - MC4 receptor agonist studied in melanocortin signaling.