PT-141
MC4 Receptor Agonist - Bremelanotide - MC4 receptor agonist studied in melanocortin signaling.
PT-141 (Bremelanotide) is a melanocortin-receptor agonist and metabolite of Melanotan II, studied for its central role in melanocortin-receptor signaling research via the MC4 receptor.
PT-141 (Bremelanotide) is the more receptor-selective metabolite of Melanotan II, focusing on central MC4 signaling, and a bremelanotide product has reached regulatory approval for a specific indication. Research here centers on that central pathway rather than pigmentation.
PT-141 specifications
- CAS number
- 189691-06-3
- Molecular formula
- C50H68N14O10
- Molecular weight
- 1025.16 g/mol
- Sequence
- Bremelanotide - cyclic heptapeptide
- Residues
- 7 residues (cyclic)
- Presentation
- Lyophilized powder
- Documented purity
- 99.60% by HPLC
- Available sizes
- 10mg ($30)
- Archived COA lots
- 7
- Intended use
- Laboratory research use only. Not for human or veterinary use.
Studied pathways
- MC4 receptor - Studied for central-nervous-system arousal signaling distinct from vascular pathways.
Reported mechanisms in the literature
- Central arousal signaling - A melanocortin-receptor agonist and metabolite of Melanotan II, studied for central arousal signaling via the MC4 receptor, distinct from vascular pathways. (Molinoff et al.)
What PT-141 is researched for
- Central signaling - Studied for central arousal signaling via the MC4 receptor, distinct from vascular pathways. (Molinoff et al.)
- MC4 pharmacology - Investigated as a receptor-selective bremelanotide in melanocortin research. (Diamond et al.)
PT-141 certificates of analysis on file
Every lot below was tested by an independent laboratory and the full report is published as a PDF. Purity is shown exactly as the report states it. The same records are searchable in the COA library and can be checked on the lot verification page.
| Lot | Tested | Size | Laboratory | HPLC purity | Identity | Certificate |
|---|---|---|---|---|---|---|
| PT141-101926-10 | 22 Oct 2026 | 10mg | ILS Laboratories | 99.90% | Confirmed (HPLC retention time) | COA PDF |
| D85YB7 | 7 Oct 2026 | 10mg | Freedom Diagnostics | 99.95% | Confirmed (LC-MS/MS) | COA PDF |
| P4110-WM2608-01 | 4 Sep 2026 | 10mg | Accurate Test Labs | 99.83% | Confirmed (LC-MS/MS) | COA PDF |
| Z7HUJW | 19 Aug 2026 | 10mg | Accurate Test Labs | 99.91% | Confirmed (LC-MS/MS) | COA PDF |
| FD-2605110192 | 11 May 2026 | 10mg | Freedom Diagnostics | 99.91% | Confirmed (LC-MS/MS) | COA PDF |
| FD-2602180081 | 20 Feb 2026 | 10mg | Freedom Diagnostics | 99.95% | Confirmed (LC-MS/MS) | COA PDF |
| FD-2512100009 | 11 Dec 2025 | 10mg | Freedom Diagnostics | 99.91% | Confirmed (LC-MS/MS) | COA PDF |
Published literature on PT-141
The mechanisms above trace to peer-reviewed studies indexed on PubMed. These are independent third-party publications, not Aspect Peptides claims. Browse indexed research on PubMed.
PT-141 frequently asked questions
What is PT-141?
PT-141 (Bremelanotide) is a melanocortin-receptor agonist and metabolite of Melanotan II, studied for central arousal signaling via the MC4 receptor.
Is PT-141 approved?
A bremelanotide product is approved for a specific indication under prescription, but this material is not sold as a medicine - it is supplied for laboratory research only.
What is it researched for?
MC4-receptor activation and central-nervous-system arousal signaling.
Documented to 99.60% purity by HPLC · third-party COA every lot · from $30 · For laboratory research use only.
Related Melanocortin & Tone compounds
- Melanotan II - Melanocortin agonist studied for pigmentation research.
- Kisspeptin - Upstream regulator of the reproductive hormone axis.