Semax
ACTH-Derived Research Peptide - ACTH-derived peptide studied for neuroprotection and cognitive modulation.
Semax is a synthetic peptide derived from a fragment of adrenocorticotropic hormone, studied for its reported neuroprotective and cognitive-modulating activity in Russian and preclinical research.
Semax is a mainstay of Russian neuropeptide research, where it is studied for neuroprotective and cognitive endpoints, and much of its primary literature is published in that context. Its short ACTH-derived sequence and reported BDNF effects make it a frequent subject in neural-plasticity models.
Semax specifications
- CAS number
- 80714-61-0
- Molecular formula
- C37H51N9O10S
- Molecular weight
- 813.93 g/mol
- Sequence
- Pro-Gly-Pro heptapeptide (ACTH 4-10 analog)
- Residues
- 7 residues (MEHFPGP)
- Presentation
- Lyophilized powder
- Documented purity
- 99.72% by HPLC
- Available sizes
- 10mg ($55)
- Archived COA lots
- 5
- Intended use
- Laboratory research use only. Not for human or veterinary use.
Studied pathways
- BDNF expression - Studied for upregulation of brain-derived neurotrophic factor in neural models.
- Neuroprotection - Investigated for protective activity under ischaemic and oxidative stress conditions.
Reported mechanisms in the literature
- BDNF expression - An ACTH(4-10) analog studied for upregulation of brain-derived neurotrophic factor and downstream neural-plasticity signaling. (Myasoedov et al.)
- Neuroprotection - Investigated for protective activity under ischaemic and oxidative-stress conditions in Russian and preclinical neuro-research. (Ashmarin et al.)
What Semax is researched for
- Ischaemia models - Studied for neuroprotection under ischaemic and oxidative-stress conditions. (Ashmarin et al.)
- Plasticity & focus - Investigated for BDNF-linked neural-plasticity and cognitive endpoints. (Myasoedov et al.)
Semax certificates of analysis on file
Every lot below was tested by an independent laboratory and the full report is published as a PDF. Purity is shown exactly as the report states it. The same records are searchable in the COA library and can be checked on the lot verification page.
| Lot | Tested | Size | Laboratory | HPLC purity | Identity | Certificate |
|---|---|---|---|---|---|---|
| N52669 | 16 Oct 2026 | 10mg | Freedom Diagnostics | 99.74% | Confirmed (LC-MS/MS) | COA PDF |
| NRPR1R | 12 Sep 2026 | 10mg | Freedom Diagnostics | 99.90% | Confirmed (LC-MS/MS) | COA PDF |
| HKUDQ4 | 27 Jul 2026 | 10mg | Accurate Test Labs | 99.08% | Confirmed (LC-MS/MS) | COA PDF |
| 2604200519 | 22 Apr 2026 | 10mg | Freedom Diagnostics | 99.90% | Confirmed (LC-MS/MS) | COA PDF |
| SEMX10-042026-3 | 15 Apr 2026 | 10mg | Freedom Diagnostics | 99.11% | Confirmed (LC-MS/MS) | COA PDF |
Published literature on Semax
The mechanisms above trace to peer-reviewed studies indexed on PubMed. These are independent third-party publications, not Aspect Peptides claims. Browse indexed research on PubMed.
Semax frequently asked questions
What is Semax?
A synthetic peptide derived from a fragment of adrenocorticotropic hormone, studied for neuroprotective and cognitive-modulating activity, largely in Russian and preclinical research.
Is Semax approved for human use?
It is registered for some uses in Russia but is not an FDA-approved drug in the US. It is supplied here for laboratory research only.
What is it researched for?
BDNF signaling, neuroprotection and cognition in cell and animal models.
Documented to 99.72% purity by HPLC · third-party COA every lot · from $55 · For laboratory research use only.